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Ciprofloxacin Ciplox

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SKU: ANT009 Categories: ,
Brands:Ciplox

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Description

Ciprofloxacin is a broad-spectrum antimicrobial carboxyfluoroquinoline.

The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.

Ciprofloxacin is used for the treatment of the following infections caused by susceptible organisms: urinary tract infections, acute uncomplicated cystitis, chronic bacterial prostatitis, lower respiratory tract infections, acute sinusitis, skin and skin structure infections, bone and joint infections, complicated intra-abdominal infections (used in combination with metronidazole), infectious diarrhea, typhoid fever (enteric fever), uncomplicated cervical and urethral gonorrhea, and inhalational anthrax (post-exposure).

Brand

Ciplox

Additional information

Doses

500/125mg

Package

30 pills, 60 pills, 90 pills, 120 pills, 180 pills

Pharmacodynamics

Ciprofloxacin is a broad-spectrum antiinfective agent of the fluoroquinolone class. Ciprofloxacin has in vitro activity against a wide range of gram-negative and gram-positive microorganisms.

The mechanism of action of quinolones, including ciprofloxacin, is different from that of other antimicrobial agents such as beta-lactams, macrolides, tetracyclines, or aminoglycosides; therefore, organisms resistant to these drugs may be susceptible to ciprofloxacin.

There is no known cross-resistance between ciprofloxacin and other classes of antimicrobials. Notably the drug has 100 times higher affinity for bacterial DNA gyrase than for mammalian.

Mechanism of action

The bactericidal action of ciprofloxacin results from inhibition of the enzymes topoisomerase II (DNA gyrase) and topoisomerase IV, which are required for bacterial DNA replication, transcription, repair, strand supercoiling repair, and recombination.

Metabolism

Metabolism: Hepatic. Four metabolites have been identified in human urine which together account for approximately 15% of an oral dose. The metabolites have antimicrobial activity, but are less active than unchanged ciprofloxacin.

Absorption: Rapidly and well absorbed from the gastrointestinal tract after oral administration. The absolute bioavailability is approximately 70% with no substantial loss by first pass metabolism.

Route of elimination: Approximately 40 to 50% of an orally administered dose is excreted in the urine as unchanged drug.

Half life: 4 hours

Affected organisms: Enteric bacteria and other eubacteria.

Side effects

All medicines may cause side effects, but many people have no, or minor, side effects.Some medical conditions may interact with Ciprofloxacin.

Tell your doctor or pharmacist if you have any medical conditions.

Common ciprofloxacin side effects may include: nausea, vomiting, diarrhea, stomach pain, vaginal itching or discharge, headache or abnormal liver function tests.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider.

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